MIF and chronic obstructive pulmonary disease: and identified that the individual cohorts of healthy controls, COPD and CHF patients, depicted lower levels of growth factors (irisin) and higher levels of protein turnaround (amino-terminal pro-peptide of type III procollagen, P3NP), neuromuscular junction integrity (c-terminal agrin fragment 22 (CAF22), osteonectin (cell–matrix interaction), cellular metabolism (fatty acid-binding protein 3, FABP3), and systemic inflammation (macrophage migration inhibitory factor, MIF).