HRK and colorectal carcinoma: We next analyzed the expression of CPAN _ DEGs in CRC compared to normal tissues, Fig 4A showed that WT1, GSDMC, CSF2 and NOS1 emerged as significantly elevated in the tumors than in normal tissues, and TNFRSF13B, HRK, UNC5D, ADIPOQ, CIDEA, GCG and ELANE expression were significantly reduced.