The investigation found that there are many muscle tissue factors that regulate bone tissue activity, and sarcopenia can affect various regulatory factors related to bone remodeling, such as insulin-like growth factor (IGF-1), fibroblast growth factor (FGF-2), interleukins (IL-6, IL-15), myostatin, bone glycine, and irisin. This evidence concerns the gene FNDC5 and sarcopenia.