The multivariable analysis showed that metastatic disease (AHR = 4.2, CI: 1.5–11.5), baseline carcinoembryonic antigen level ≥5ng/ml (AHR: 2.4, CI: 1.2–5.8), living in rural areas (AHR = 2.2, CI:1.03–4.8) and mucinous carcinoma (AHR = 0.33, CI: 0.13–0.87) were independent predictors of colorectal cancer mortality. This evidence concerns the gene CEACAM5 and colorectal cancer.