ABX-EGF Monoclonal Antibody binds EGFR with high affinity(5 × 10–11 M),7 blocksthe binding of both EGF and transforming growth factor-α (TGF-α)to various EGFR-expressing human carcinoma cell lines, and inhibitsEGF-dependent tumor cell activation. The gene discussed is EGFR; the disease is neoplasm.