Notably, in cases with chromothripsis on chromosome 12, co-amplification of MDM2 (a potent p53 antagonist), together with CDK4 and CCND2 (pRb antagonists), may represent a full phenocopy of the TP53 and RB1 genomic co-inactivation in conventional SCLC. The gene discussed is TP53; the disease is small cell lung carcinoma.