Furthermore, in a cohort of 3,600 SCLC samples submitted for broad targeted next-generation sequencing (tNGS) at Foundation Medicine, 5.5% were reported to lack RB1 and TP53 alterations; this subset harbored instances of CCND1 and MDM2 amplification, but no WGS or detailed clinicopathologic characterization of these samples was available (3). This evidence concerns the gene TP53 and small cell lung carcinoma.