Thus, we can speculate that sustained mTOR activity, especially increased synaptic levels of downstream effectors (p-mTOR and total p70S6K) in the hippocampus, plays an important role in the resilience of GluN2A−/− mice to depression, which also confirms mTOR-mediated synaptic function (Zhou et al., 2023). This evidence concerns the gene MTOR and major depressive disorder.