Three novel CHDT-functionalizedPSMA inhibitors were synthesized and their Al18F-, 68Ga-, and 111In-labeled analogs were subjectedto a detailed in vitro radiopharmacological characterization.Stability studies in vitro in human serum revealedamong others a high kinetic inertness of all radiometal complexes.Furthermore, the Al18F-labeled PSMA ligands were characterizedfor their biodistribution in a LNCaP derived tumor xenograft mousemodel by PET imaging. The gene discussed is FOLH1; the disease is neoplasm.