One radioligand, Al[18F]F-CHDT-PSMA-1, bearing a small azidoacetyllinker at the glutamate-urea-lysine motif, provided an invivo performance comparable to that of [18F]PSMA-1007 but with even highertumor-to-blood and tumor-to-muscle ratios at 120 min p.i. Overall, our results highlight the suitability of the novel CHDTmoiety for functionalization and radiolabeling of small moleculesor peptides with Al18F, 68Ga, and 111In and the triazole ring seems to entail favorable pharmacokineticproperties for molecular imaging purposes. The gene discussed is FOLH1; the disease is neoplasm.