We performed the subcellular fractionation experiment to compare the distribution of TDP‐43, and confirmed that TDP‐43 was distributed in the ribosome and that this ribosomal distribution was increased in HD KI mouse striatum (Figure 6a,b) and was also elevated by cytoplasmic TDP‐43 in either WT or HD KI mouse striatum (Figure 6c,d and Figure S11). Here, TARDBP is linked to Huntington disease.