The immunofluorescent double‐staining with anti‐TDP‐43 and anti‐Htt (mEM48) of the WT, HD KI and the ΔNLS‐TDP‐43 injected individuals, revealed that the endogenous TDP‐43 was mostly located in the nucleus of WT mouse striatum, but mislocalized in cytoplasm of age‐matched HD KI mouse, and co‐existed with Htt aggregates especially (Figure 3c). This evidence concerns the gene TARDBP and Huntington disease.