Although TDP‐43 was found in the cytoplasmic stress granules in R6/2 mice that overexpress transgenic exon1 mutant Htt (Sanchez et al., 2021), it remains unknown whether cytoplasmic TDP‐43 is increased in HD KI mice that express full‐length mutant Htt at the endogenous level and whether cytoplasmic TDP‐43 can exacerbate the phenotypes of HD mice. This evidence concerns the gene HTT and Huntington disease.