TARDBP and Huntington disease: Next, to explore whether the pathogenic TDP‐43 in the cytoplasm plays a causative role in HD pathogenesis, we expressed the full‐length TDP‐43 (WT‐TDP‐43) and the cytoplasmic TDP‐43 (ΔNLS‐TDP‐43) without nuclear localization signal in Neuro‐2a cell line (Figure 2a), which was also described in our early study (Yin et al., 2021).