Another factor would be the chronic inflammation state in CD patients leading to the release of cytokines such as TNF‐alpha, which can also decrease the levels of proteins C and S.19While CD individually confers a higher risk of DVT, the acute inflammation and production of cytokines such as TNF‐alpha, IL1, IL6, and IL10 in patients with AP have also been found to activate the coagulation cascade and inhibit the anticoagulation pathways.20 This evidence concerns the gene IL6 and alkaline phosphatase measurement.