It is very specific to Everyday Memory, Everyday Language, Everyday Visuospatial abilities, and three everyday executive domains including Everyday Planning, Everyday Organization, and Everyday Divided Attention Moreover. ECog designed as questionnaire. ECog has good reliability as well as concurrent, it is sensitive to very early functional difficulties, and is associated with other disease markers such as the presence of amyloid and tau. Here, MAPT is linked to amyloidosis.