Through the regulation of the Wnt/GSK-3β/β-catenin signaling pathway, it has been observed that Rg1 administered at moderate and high doses exhibits the potential to mitigate oxidative stress-induced damage, ameliorate neuroinflammation, safeguard neurons, and ultimately enhance cognitive impairment in the AD model of the tree shrew. This evidence concerns the gene GSK3B and Alzheimer disease.