Notably, the ε4 allele of the apolipoprotein E gene (APOE ε4) is strongly correlated with fibrillary Aβ burden and Aβ aggregation in late-onset AD, driving amyloid pathology and dystrophic neurites in murine models and human neurons (Huynh et al., 2017; Kim et al., 2022). The gene discussed is APOE; the disease is Alzheimer disease.