APOE and Alzheimer disease: The acceleration of AD-related pathologies occurs when APOE ε4 increases Aβ production by accelerating APP endocytosis transport mediated by low-density lipoprotein receptor-related protein, thereby initiating and promoting the accumulation, aggregation, and deposition of Aβ in the brain (Pietrzik et al., 2002; Tachibana et al., 2019).