Histopathological examinations revealed poorly-differentiated carcinoma in the recurrent suprarenal area biopsy; b) microscopic findings suggestive of adrenocortical carcinoma from a post-operation tumor tissue; c) immunohistochemical test show negative results for inhibin, calretinin, and CK, which are markers commonly used in the diagnosis of adrenocortical carcinomas, but positive for vimentin, synaptophysin, chromogranin, and CD56 confirming neuroendocrine carcinoma diagnosis (Fig. 3). Here, SYP is linked to adrenal cortex carcinoma.