In this study, utilizing MR analysis for the first time, we discovered that hypothyroidism can lead to changes in the expression levels of 26 plasma proteins, including CXCL13, VAMP1, and CXCL10, among which CXCL10 may mediate the impact of hypothyroidism on the risk of developing IPF. Here, CXCL10 is linked to idiopathic pulmonary fibrosis.