GO enrichment analysis showed that hypothyroidism candidate genes were significantly enriched in biological processes such as positive regulation of the production of molecular mediators of immune response, positive regulation of cytokine production involved in immune response, regulation of T cell receptor signaling pathway, thyroid hormone generation, endocytic vesicle membrane, lamellipodium, WASH complex, pattern recognition receptor activity, receptor tyrosine kinase binding, and cytokine receptor activity (Figures 5C, E, G). This evidence concerns the gene TG and hypothyroidism.