Some of the highly synthesized IgG autoAbs that were depleted in the BAFF-neutralized mice target C-reactive protein, tissue transglutaminase, aquaporin 4, and complement C1q, and these proteins are associated with obesity-induced WAT inflammation and increase in IR (50–53). The gene discussed is TNFSF13B; the disease is obesity due to melanocortin 4 receptor deficiency.