IFNG and tuberculosis: Its role in detecting Mtb infection has paved the way for the development of various diagnostic tests, such as the QuantiFERON-TB Gold In-Tube test (QFT-GIT) (97, 98) and T-SPOT.TB assay (99), which utilize IFN-gamma release assays (IGRAs) to measure serum levels of Mtb-specific interferon-gamma (IFN-gamma) release (100).