Therefore, a 4-transcript signature (GBP6, TMCC1, PRDM1, and ARG1), derived from the 44-transcript signature (62), distinguishes TB from other diseases with an AUC of 0.938; a 3-gene transcript (FCGR1A, ZNF296, and C1QB), derived from the 27-transcript signature (62), separates TB from LTBI with an AUC of 0.973 (27). This evidence concerns the gene ZNF296 and tuberculosis.