We went on to show that during infection with retroviruses like murine leukemia virus (MLV) and human immunodeficiency virus (HIV), DDX41 primarily senses the DNA/RNA hybrid generated during the initial step of viral reverse transcription, particularly in dendritic cells, the initial targets of MLV infection, and that this then activated the STING pathway (5) (Figure 2). This evidence concerns the gene DDX41 and infection.