This protein interacts with TRAF6, self-ubiquitination modification of TRAF6, activates TAK1, and ultimately stimulates NF-κB and JNK/P38/ERK signaling pathways, which participate in the colon inflammation in IBD; 2 MyD88 signaling pathway can also be used as another pathway for TLR to induce inflammation. Here, NFKB1 is linked to inflammatory bowel disease.