Therefore, in this study, DNA samples from 115 children and young adults with T1D were typed for HLA-A, -B, -C, -DRB1, -DRB3/4/5, -DQA1, -DQB1, -DPA1 and -DPB1 by NGS (Next Generation Sequencing), with the aim of investigating the role of these genes on T1D risk and age at onset. The gene discussed is HLA-DPB1; the disease is type 1 diabetes mellitus.