The high-risk genotype HLA-DRB1*03-DQA1*0501-DQB1*0201/DRB1*0401-DQA1*0301-DQB1*0302 was strongly associated with the onset of diabetes before the age of 5 years and that the frequency of this genotype in T1D subjects decreased with increasing age at onset (17). The gene discussed is HLA-DRB1; the disease is type 1 diabetes mellitus.