Studies have identified that p53 regulates ferroptosis processes within extra-nodal NK/T-cell lymphoma (ENKTCL) cells by affecting GSH synthesis by inhibiting SLC7A11 expression, leading to reduced GPX4 activity and subsequent ferroptosis induction (66) The pathway involving p53/SLC7A11/GPX4 also plays a role in ferroptosis in cholangiocarcinoma cells. The gene discussed is TP53; the disease is cholangiocarcinoma.