IL18 and hepatocellular carcinoma: p53 can also regulate the production of these cytokines in the TME, and an experiment on a mouse model of hepatocellular carcinoma found that p53 activation promoted the promotion of the pro-inflammatory cytokines IL-12, IL-15, and IL-18 in the TME, and p53 is directly linked to the regulatory sequence of the CCL2 gene, p53 in hepatocellular carcinoma cells can recruit NK cells by inducing chemokine expression, thereby facilitating the elimination of tumor cells by NK cells (77).