Use of a murine pan-TGFβ neutralising antibody 1D11 in a severe OI mouse model (Crtap−/−) reduced bone resorption (CTX biomarker 25 % ± 5 % lower) and significantly increased spine bone volume (235 % increase in BV/TV) (Song et al., 2022). Here, TGFB1 is linked to osteogenesis imperfecta.