Similarly, to fibroblasts isolated from OI patients and other mouse models of OI (Greene et al., 2021; Song et al., 2022), OIM mice used in the current study (Phillips et al., 2000) expressed higher concentrations of plasma TGFβ (79.2 ± 14.6 ng/ml) compared with control, C57BL/6 mice (51.7 ± 6.1 ng/ml; data not shown). This evidence concerns the gene TGFB1 and osteogenesis imperfecta.