Previous results reported a positive correlation between the expression of DNMT3B and that of m6A “reader” YTHDF1 and IGF2BP1. We speculate that the modification of m6A may lead to an increase in the expression of DNMT3B, during which YTHDF1 or IGF2BP1 recognizes the m6A modification site of DNMT3B mRNA, thus stabilizing DNMT3B mRNA and promoting the occurrence and development of GC. Here, IGF2BP1 is linked to gastric cancer.