These genes include like PIK3CA, which is involved in the oncogenic PI3K/AKT/mTOR signaling pathway; MMP9 and MMP2, which promote tumor migration; CASP8 and CASP3, which are involved in the apoptosis process; and MDM2, which regulates the stability of the tumor suppressor gene p53. The gene discussed is CASP8; the disease is neoplasm.