TNF and Hepatic fibrosis: Additionally, Hernandez-Ortega et al. (Hernandez-Ortega et al., 2012) found that quercetin reduced AST, ALT, and GGT levels in mice with liver fibrosis, decreased the area of liver fibrosis and collagen deposition, increased SOD, CAT serum enzymes and mRNA levels, inhibited inflammation by reducing the expression of markers TNF-α, IL-6, TGF-β1, COL1α1, CTGF, TIMP-1, and α-SMA, induced HSCs apoptosis, and increased the expression of anti-liver fibrosis molecules TGF-β1, MMP2, and MMP9.