ApoE is a transporter of amyloidβ, a widely recognized biomarker in AD development.11 ApoE-isoforms modulate brain mRNA expression, presumably in response to changes in lipid availability11 as well as direct transcriptional effects.12 Here we used both quantitative and kinetic proteomics to explore the impact of human ApoE genotypes in the proteome of mice. Here, APOE is linked to Alzheimer disease.