So far, specific tau folds have defined different diseases, even though the same fold can be found in multiple conditions, such as the chronic traumatic encephalopathy (CTE) fold in CTE, subacute sclerosing panencephalitis (SSPE), amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) and vacuolar tauopathy (VT) [2,42]. The gene discussed is MAPT; the disease is amyotrophic lateral sclerosis.