Similarly, enrichment of the IFN-γ+ Th1-like subset (cluster 1) was observed only in tumors from SFB colonized mice (Figure 3c), highlighting the distinct transcriptional profiles and subset distributions of CD4+ T cells in the intestinal and tumor environments of SFB-colonized mice, which likely play a crucial role in mediating the observed anti-tumor immune response in SFB-colonized mice. The gene discussed is CD4; the disease is neoplasm.