PRF1 and neoplasm: In the SFB-colonized mice, the tumor-associated T cells sharing clonotypes with SILP T cells were characterized by upregulation of genes associated with cell trafficking, such as Cxcr6, chemoattraction, including Ccl3 and Ccl4 (potent chemoattractants for various immune cells, including cytotoxic T cells, dendritic cells, NK cells, and macrophages), pro-inflammatory cytokines Ifng and Tnf, and cytolytic functions including Prf1, Klrc1, and Klrd1, which together contribute to anti-tumor immunity (Figure 3g and Extended Data Fig. 6d, e).