CD4 and neoplasm: Next, analysis of sequences of paired TCR α and β chain transcripts revealed numerous clonal relationships of CD4+ T cells with Th17 or follicular helper (Tfh) phenotype in the SILP and Th1-like phenotype in the B16-3340 tumors of SFB colonized mice, consistent with the intestinal origin of the tumor-infiltrating, trans-differentiated T cells that expanded in the tumor microenvironment (Figure 3d–f).