Next, given that effective tumor growth control requires a synergistic effect involving both CD4+ and CD8+ T cells working in conjunction with ICB32–34, we aimed to investigate whether the combination of SFB colonization-induced CD4+ and tumor-infiltrating CD8+ T cells, together with anti-PD-1 treatment, is essential for controlling the growth of SFB-3340-expressing tumors. The gene discussed is CD4; the disease is neoplasm.