S1PR2 and autism: Comparing high vs. low adaptive longevity in controls only, we found thirty-four upregulated DEGs in the Ant-Ins (Table S3A), including the GTPase and metal iron binding gene implicated in autism AGAP7P gene, G-protein coupled receptor S1PR2, and LPAR4 genes, Leucine-rich LRRC69 gene, DNA binding transcription factor SHOX, antisense RNA WT1-AS gene, fibroblast growth factor 23 FGF23 anti-aging gene (Haussler et al. 2016), the pregnancy-specific Beta-1-Glycoprotein 2 PSG2 (Khan et al. 1992) gene, and several other genes and pseudogenes (Table S3A; Fig 6A).