Our analysis of DEGs in the sgACC associated with suicide completion vs. non-suicide deaths (excluding controls) identified predominantly downregulated DEGs, including downregulated markers (i.e., 313 of 332 markers were downregulated), including three members of the cell growth inhibiting serpine family of proteins SERPINA3, SERPINE1, and SERPINA1 (implicated in schizophrenia, Alzheimer’s, and Parkinson’s diseases and Ant-Ins regional DEGs in suicide completers), the inflammation mediator CHI3L1 (downregulated in Ant-Ins in suicide completers). Here, SERPINA3 is linked to Parkinson disease.