Our identified DEGs in the Ant-Ins in MDD vs. controls included five genes, namely: a downregulated SELE gene known to control leukocyte regulation of inflammation, and four upregulated genes including the cytokine interleukin-1 receptor-like IL1RL1 gene, a gene that regulates IL-33/ST2 (Uversky 2014), a phosphorylated protein binding FBXO47 gene, a mitochondrial electron transporter MTCO2P12, and a long-noncoding RNA (lncRNA) H19 in the Ant-Ins (Table 2A). This evidence concerns the gene IL1RL1 and major depressive disorder.