Within this context, we have selected 12 polymorphisms located in five genesCXCL8 (rs4073, rs2227306, rs2227307, rs188378669),TNF (rs361525, rs1800629),IL1B (rs16944, rs1143634, rs1142639, rs1143627),IL6 (rs1800795), andIL10 (rs1800896) for correlation analysis, as candidate genetic modulators of the pulmonary or digestive manifestation and severity of the disease among Polish CF patients. The gene discussed is IL1B; the disease is cystic fibrosis.