We found that NSUN7, SLC6A8, CXCL1 and LCN8 were significantly different in groups B compared to A, and SLC1A3 and LCN8 were significantly different in groups C compared to A. NSUN7, a m5C RNA methyltransferase gene, is differentially expressed in Alzheimer's disease patients (24). The gene discussed is LCN8; the disease is early-onset autosomal dominant Alzheimer disease.