Gene panel sequencing for TAAD-associated genes identified two candidate causal missense variants in MYLK and FBN1. FBN1 is the causative gene for MFS, the most common inherited form of syndromic TAAD, but FBN1 rare variants and polymorphisms have been also reported to contribute to nonsyndromic TAAD [8, 9]. The gene discussed is FBN1; the disease is Marfan syndrome.