Currently, rare variants and polymorphisms in FBN1 (OMIM∗134797), which cause Marfan syndrome (MFS), have also been reported to be involved in nonsyndromic TAAD [8, 9]; however, when assessing the pathogenicity of unclassified variants, it is important to ensure that preventive measures are taken. The gene discussed is FBN1; the disease is Marfan syndrome.