MSC soluble factors can attenuate scar formation [46] by inhibiting protein expression of heat shock factor (HSF)-derived nuclear factor kappa B (NF-κB), alpha-smooth muscle actin through the delivery of miR-138-5p to target Sirtuin-1 (SIRT1) and promoting apoptosis of keloid fibroblasts [50]. This evidence concerns the gene NFKB1 and keloid.