Results revealed that there was a highly statistically significant difference in the patients' group when compared to the control group regarding the levels of NEAT-1 and p53 with mean and standard deviation of 5.10 ± 1.16 and 277.28 ± 62.02 for the MF patients' group and 1.01 ± 0.031 and 194.29 ± 16.039 for healthy controls with p values 0.001 and 0.0001, respectively. This evidence concerns the gene TP53 and mycosis fungoides.