ALCAM and cancer: Recent studies have shown a strong correlation between the expression of CD166 and the presence of Cancer Stem Cells (CSCs) in various types of cancer, such as lung (El-Ashmawy et al., 2021), colorectal (Han et al., 2017), and gastric cancers (Nguyen et al., 2017), highlighting CD166 as a significant marker for CSCs in these malignancies.