Furthermore, CD44 is associated with the dysregulation of the Wnt/β-catenin signaling pathway, which is more active in CD44 and CD133 enriched cells, further enhancing tumor proliferation and malignant transformation (Wielenga et al., 1999; Hao et al., 2010; Ishimoto et al., 2011). This evidence concerns the gene CD44 and neoplasm.