Among the many causes of LRH include primary aldosteronism (sporadic/familial), pseudo-hypoaldosteronism type 2 (Gordon syndrome), Liddle syndrome, apparent mineralocorticoid excess, CYP11B1 deficiency, CYP17A1 deficiency, mineralocorticoid receptor activating mutation, glucocorticoid resistance, licorice/grapefruit juice use, nonsteroidal anti-inflammatory drugs (NSAIDs), COX-2 inhibitors, heparin, ectopic adrenocorticotropic hormone (ACTH) production, deoxycorticosterone-producing tumors, very-high-salt diet, and LREH (Figure 1). Here, POMC is linked to Increased circulating aldosterone concentration.