TTP is characterized by von Willebrand factor (VWF) platelet thrombi in the arterioles and capillaries of multiple organs due to the deficiency of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) [11]. The gene discussed is VWF; the disease is thrombotic thrombocytopenic purpura.