In their research, NT-proBNP was significantly linked to three-point major adverse cardiovascular events (3P-MACE), which included cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke, as well as five-point major adverse cardiovascular events (5P-MACE), which added heart failure hospitalisation and revascularisation procedures [9]. This evidence concerns the gene NPPB and stroke disorder.