ANXA5 and Rare hereditary thrombophilia: It is the second most common thrombophilia [7]. The presence of double heterozygosity for Factor V Leiden and PRT20210G/A is a cumulative risk factor for thrombotic events. With regard to thrombophilias, ANXA5 M1/M2 and PAI-4G/4G mutation are two risk factors associated with obstetric complications.