Cleidocranial dysplasia (CCD) is a genetic disorder of bones that originates from the mutation in the runt-related transcription factor 2 (RUNX2) and follows an autosomal dominant highly polymorphic skeletal trait with variable penalties that primarily involve the bones that are formed through the process of intramembranous ossification [1]. The gene discussed is RUNX2; the disease is cleidocranial dysplasia 1.