The study proved that GMSC-Exos reduced the inflammatory immune response of periodontitis by regulating the Wnt5a-mediated RANKL pathway [71], and pretreatment of GMSC-Exos with TNF-α could upregulate miR-1260b to further inhibit Wnt5a, thereby contributing to the resolution of inflammation [69]. This evidence concerns the gene WNT5A and periodontitis.