Some publications investigated the relationship between VEGF-A in the vitreous or aqueous humor and ROP, reporting higher VEGF-A levels in severe stages of ROP compared with controls or a group with vascularly inactive ROP.89, 90, 91 Conversely, 1 study measuring VEGF-A in tear fluid reported lower levels in infants with ROP.92 Here, VEGFA is linked to retinopathy of prematurity.