APP and Alzheimer disease: Nonetheless, this pattern of results is consistent with previous work demonstrating that more severe TBIs are associated with more long-term deficits51 and greater risk for AD.26,27 More severe injuries induce greater neurometabolic disruptions,52 including aberrant APP processing,53 suggesting that more severe injuries may exacerbate the genetic pathways of AD more than milder injuries, consequently leading to greater Aβ plaque accumulation.