Furthermore, peaks that displaying increased accessibility in AD/ADRD cerebellum were enriched for motifs of key TFs, such as Zinc Finger and BTB Domain Containing 14 (ZBTB14) and Zic Family Member 2 (ZIC2) in mature granule cells, and Zinc Finger Binding Protein 385D (ZNF385D) and SP4 Transcription Factor (SP4) in Purkinje cells (Figure S5C). This evidence concerns the gene SP4 and Alzheimer disease.