BDNF and Alzheimer disease: Genes linked to those AD/ADRD affected peaks were significantly enriched in multiple key biological pathways (Table S8), including metabolic pathways (q = 7.40 × 10−18), amyotrophic lateral sclerosis (q = 6.04 × 10−16), pathways of neurodegeneration (q = 3.28 × 10−12), neurotrophin signaling pathway (q = 3.50 × 10−10), and spinocerebellar ataxia (q = 2.00 × 10−9).