Loss of PDE10A expression is associated with progression and severity in Parkinson’s disease.31 Furthermore, there was significant overlap between disease-associated DEGs and cell type-specific marker genes, and between cell type-specific DEGs and cCRE-linked genes within that cell type (Fisher’s exact test P < 0.05, Figure 3C), highlighting a critical role of cCREs in disease-associated transcriptomic changes. This evidence concerns the gene PDE10A and Parkinson disease.