These genes included previously nominated AD GWAS genes, including Microtubule Associated Protein 2 (MAPT), Speedy/RINGO Cell Cycle Regulator Family Member E3 (SPDYE3), Nuclear Receptor Subfamily 1 Group H Member 3 (NR1H3), and Proteasome 26S subunit ATPase 3 (PSMC3) and immune modulators of TNF-alpha signaling pathway (Mitogen-Activated Protein Kinase Kinase Kinase 3 [MAP3K3] and MAP Kinase Activating Death Domain [MADD]). The gene discussed is SPDYE3; the disease is Alzheimer disease.