Joint analyses of the transcriptome and chromatin profiles in the same nuclei enables greater confidence in combining the correlations between cCREs and TF binding motifs and between TF activity and target gene expression.15 Through peak-to-gene linkage analysis, we found common and unique transcriptomic and epigenomic signatures and associated gene networks in AD cerebellum with frontal cortex, such as the key AD GWAS-linked gene BIN154 and IL3355, providing potential targets for further study in AD cerebellum. Here, TF is linked to Alzheimer disease.