We found 2,705 cis-regulatory linked genes between cerebellum and frontal cortex, including multiple known AD/ADRD causal genes, such as Apolipoprotein E (APOE), Bridging Integrator 1 (BIN1), Arichidonate 5-Lipoxygenase (ALOX5), and FYN. The gene discussed is ALOX5; the disease is Alzheimer disease.