TF and Alzheimer disease: This enabled molecular investigation of underlying neuropathological changes within human AD/ADRD cerebellum, which was previously described only by neuroimaging and anatomical studies.2,4 We also identified unique transcriptomic and epigenomic signatures and gene networks/pathways across diverse cell types or subpopulations, as well as how molecular interactions between TF binding sites and cCREs contribute to those transcriptomic changes.