PALB2 and medulloblastoma: Homozygous and compound heterozygous BRCA2 and PALB2 P/LP variants have also been identified in a subset of patients with SHH subgroup medulloblastoma with Fanconi Anemia caused by homologous recombination repair deficiency, though the estimated risk of developing medulloblastoma from a single P/LP variant in BRCA2 or PALB2 remains low (15, 18).