Similar to SUFU, GPR161 variants seem to be found primarily in infant medulloblastoma; previously reported in 3.4% of pediatric SHH medulloblastoma cases (5 of 6 of our reported cases were under the age of 12 months) (17), compared to only one 10-year-old case with a P/LP GPR161 variant in our cohort. Here, GPR161 is linked to medulloblastoma.