SHH and Alzheimer disease: For the 196 AD CSGs and WNT/SHH pathway genes, the frequency of P/LP variants in all cases [12.5% (20/160)] was statistically significantly higher versus 5.1% of controls (65/1259; p=1.0 x10-3); the results were similar when restricted to cases of European ancestry (12.4% vs. 5.3%; p=2.5 x10-3).