Up-regulated expression of KIFC3 has been described in many types of cancer and is associated with Epithelial-Mesenchymal-Transition and other important events in tumor development and progression (38) KRT20 (cytokeratin 20) gene was selected as a surrogate marker (along with 3 uroplakin genes) for luminal MIBC subtype by Olkhov-Mitsel and colleagues in the analysis performed with tumoral tissue (39). The gene discussed is KRT20; the disease is neoplasm.