Vitamin D exerts therapeutic effects on bone health in the context of metabolic syndrome, regulating bone mineralization, ensuring adequate calcium and phosphate supply, modulating osteoprotegerin levels, promoting sclerostin synthesis, and modulating the immune system to reduce inflammation and lower the risk of osteoporosis and fractures, all contributing to the prevention and management of metabolic syndrome. The gene discussed is TNFRSF11B; the disease is metabolic syndrome.