Defects in PINK1/Parkin-mediated mitophagy activated platelet-derived growth factor receptor (PDGFR), an important mediator in fibrosis, which promoted FB proliferation and MFB activation, exacerbating fibrosis in IPF, a chronic progressive disease characterized by the fibrosis and hardening of lung tissue; besides, it was noted that Parkin is a major factor regulating the FB phenotype in IPF (Kurita et al., 2017; Tsubouchi et al., 2018). This evidence concerns the gene PRKN and idiopathic pulmonary fibrosis.