Similarly, inhibition of PINK1/Parkin-mediated mitophagy promoted the progression of NAFLD by activating the NLRP3 inflammasome and triggering cellular pyroptosis, a distinct form of programmed cell death characterized by inflammation, cell swelling, and rupture (Gao et al., 2022). The gene discussed is PRKN; the disease is metabolic dysfunction-associated steatotic liver disease.