Risk of T2D was the most commonly reported endocrine outcome in three reviews and one pooled analysis [65–68], followed by HOMA-IR in two reviews [67, 69], while the remaining measures indicative of insulin regulation in the body, including fasting insulin and glucose, as well as 2-hr insulin and 2-hr glucose were reported in one review (Table 2) [67]. Here, INS is linked to type 2 diabetes mellitus.