MAPT and Pick disease: Protein misfolding into insoluble amyloid deposits is a hallmark of many neurodegenerative diseases.[1] The microtubule‐associated protein tau is intrinsically disordered and highly soluble.[2, 3] Despite this, insoluble tau filaments are formed in several neurodegenerative diseases such as Alzheimer's disease (AD),[4] corticobasal degeneration (CBD),[5] chronic traumatic encephalopathy (CTE),[6] and Pick's disease (PiD).[7] Remarkably, the adopted folds of tau filaments are disease specific.[4, 5, 6, 7, 8]