MAPT and Alzheimer disease: showed that the residues at its N‐ and C‐termini are essential for filament formation in vitro because several shorter tau constructs were ineffective in forming filaments.[15] Additionally, they proved by high‐throughput cryo‐EM structure determination that dGAE can form filaments in vitro, resembling those found in the CTE and AD patient brains.[15, 16]