Gene set enrichment analyses (GSEA) in the cancer Hallmark gene set collection, using the fold change of gene expression observed in C vs. A3C KO and A3C KO vs. A3C Rec for ranking, demonstrated consistent stimulation by A3C for the “TNFA SIGNALING VIA NFκB” gene set (Fig. 2C,D and Fig. S3A,B). Here, NFKB1 is linked to cancer.